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sugarbear12 sugarbear12
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12 years ago
Can anyone explain the function of the fructose and galactose pathways please?
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wrote...
12 years ago
This attachment explains how the two pathways work, maybe it could be a little help to you.
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wrote...
12 years ago
Fructose can be handled two ways . At low concentrations of fructose , the enzyme hexokinase convertes fructose to fructose - 6-phosphate the same compound that is produced via isomerization from glucose -6- phosphate in the glycolytic pathway strating with glucose . At higher concentrations , fructokinase ( whiich has a higher Km for fructose than hexokinase ) in the liver converts fructose to fructose 1-phosphate which is cleaved by aldolase b to produce dihydroxyacetone phosphate and glyceraldehyde . the glyceraldehyde can be converted to glyceradehyde 3 -phosphate by a kinase and the pathway looks the same as normal glycolysis. However...the action of aldolaseb on fructose -1 P comes in below the rate limiting and highly regulated enzyme phosphofructokinase ( that converts fructose-6 phosphate to fructose, 1 6 bis phosphate . This means that the high levels of fructose metabolized via this route will swamp the normal glucose metabolisn pathways ( no regulation by PFK ) and thus cause fat deposition, increased glycogen storage and enhanced blood glucose ( not a great option for diabetics ). So low to minimal /moderate levels ok
wrote...
12 years ago


The purpose is to produce more the starting materials for glycolysis.
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