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lovelyturret lovelyturret
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6 years ago
Explain how the protein leptin stimulates the oxidation of fatty acids and the uptake of glucose by muscle cells.
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6 years ago
Leptin stimulates the oxidation of fatty acids and the uptake of glucose by muscle cells. It does so by stimulating the AMP-activated protein kinase, which phosphorylates an isoform of acetyl-CoA carboxylase (ACC) in muscle cells, rendering it less active. Leptin also inhibits the production of the mRNA for hepatic stearoyl-CoA desaturase, an enzyme that adds double bonds to saturated fatty acids, leading to less lipid synthesis.
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