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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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ronswanson11 ronswanson11
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6 years ago
In what ways can a primer for DNA synthesis by a DNA polymerase be provided?
 
  What will be an ideal response?
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6 years ago
Ans: DNA polymerases require a free 3-OH end of either RNA or DNA, called a primer, in order to initiate DNA synthesis. In DNA replication, this is most often accomplished by the synthesis of a short RNA sequence from the DNA template by a primase, an RNA polymerase that does not require a free 3-OH end. Primers can also be generated by the hybridization of an already synthesized RNA to the template strand, or by the nicking of a strand of the DNA. In some cases, a protein can directly prime the polymerization reaction.
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