Describe the mode of action of the ?-lactam antibiotics.

colleen

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12 years ago

Describe the mode of action of the ?-lactam antibiotics.

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sci_expert

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12 years ago

You mean beta-lactam antibiotics specifically target PBPs in bacterial cells. Bound transpeptidases (also called penicillin-binding proteins, or PBPs) are unable to cross-link peptide chains, so the result of beta-lactam antibiotics is a cell with a weak cell wall. Cells without linked cell wall peptides will eventually be lysed due to an inability to withstand osmotic pressure differences.

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