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3 months ago
A 71-year-old woman has experienced a sharp decline in her mobility and quality of life due to severe rheumatoid arthritis. As a result, her care provider has recently prescribed abatacept (Orencia). This fusion protein inhibitor will achieve a therapeutic effect by what means?
A)Preventing the activation of T cells
B)Increasing antibody production by B cells
C)Antagonizing histamine receptors
D)Inhibiting the production of mast cells
Source  Download
Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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3 months ago
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Abatacept (Orencia) is a fusion protein inhibitor synthesized from an IgG antibody fused to a cell protein that binds to antigen-presenting molecules. This action prevents the activation of T lymphocytes and the production of inflammatory cytokines. Abatacept does not increase antibody production, antagonize histamine receptors, or inhibit mast cell production.

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