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Why exactly are Okazaki fragments "fragments"?

Illy222

wrote...

Posts: 4

Rep:

3 years ago

Why exactly are Okazaki fragments "fragments"?

As I understand it, DNA polymerase on the lagging strand follows the DNA helicase while creating primer, segments known as Okazaki fragments, because it cannot immediate synthesize new DNA. Then the polymerase goes backwards and synthesizes DNA along these fragments. But why are they fragmented?

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lstar1993

wrote...

#1

3 years ago

Along the lagging strand, the DNA continually unzips, leaving a segment of nucleotides exposed. Due to the directionality of the enzyme, it adds new nucleotides in the opposite direction relative to the direction the DNA unzips, hence the discontinuity

https://videos.homeworkclinic.com/watch/527/semidiscontinuous-dna-replication/

1 Vote

bio_man

Illy222 Author

wrote...

#2

3 years ago

That animation helped, thank you.t.

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