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Polycomb group (PcG) gene mutants cause ectopic expression ofAntennapedia(Antp) and other homeotic ...

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Polycomb group (PcG) gene mutants cause ectopic expression ofAntennapedia(Antp) and other homeotic ...

Polycomb group (PcG) gene mutants cause ectopic expression of Antennapedia (Antp) and other homeotic genes. The PcG protein encoded by the PgG gene has a domain that binds to methylated histone H3. This finding supports which of the following hypotheses?

▸ that PcG binds to Antp genes and serves as a transcription activator

▸ that PcG mutants lack Antp mRNA compared to the wildtype

▸ that PcG repress transcription by interacting with chromatin

▸ that PcG activates Antp genes in tissues

▸ that PcG is allosteric activator of RNA polymerase II

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Genetic Analysis: An Integrated Approach

Edition: 3^rd

Authors: Sanders, Bowman

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