What is the wobble hypothesis, and what implications does it have for base-pairi

The wobble hypothesis refers to the degeneracy at the third nucleotide position of a codon, in which the base at the 5' of the tRNA anticodon can pair with more than one type of base at the 3' end of the codon. For example, the same leucine tRNA molecule with anticodon GAG can read two different leucine codons (CUC and CUU). This allows for neutral mutations to occur in genes at the third position, but not the first or second, of a codon. Therefore, there is said to be higher selective pressure on the first and second positions in a codon, causing mutations at those positions to be much more rare.

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