Innate immune system proteins may become a new target against bacterial infectio

Recently,scientists from St.Jude Children's Research Hospital has found a new way to effectively resist bacterial PDK2 infection,this approach to the innate immune system group is divided into target,which activates the immune effect.This study,the researchers described the main function of the innate immune molecules inhibit inflammation,in turn,can buffer the immune effects of infection or other threats.The researchers revealed the PDK3 protein can inhibit the two ways,these two pathways can control the generation of specific molecules and then"fight"with an infected.Related research published in the internationally renowned journal Nature.The researchers said this study highlights is that if we can produce the monoclonal antibodies to,and this PDK4 protein can be effective against bacterial infections.Although part of the antibiotic against bacterial infection to be effective,but the variability of bacteria will gradually develop resistance,which caused tremendous damage to human health and property.A better understanding of how the immune system recognition and the effect will be a huge help for us to develop new and effective PDP1 therapy for pathogens.

The researchers pre-focus on the receptor protein similar to the NOD 6(NLRP6)NLRP6 are part of the innate immune response component protein family,act as a sentinel role of these proteins within cells,can be identified and effects of PDP2 pathogens,as of up to now,no one knows the role played by NLRP6.Through research of whether Nlrp6 gene in mice,the researchers studied the mice's immune effects of different bacteria,these bacteria,including single-core,Listeria,Salmonella typhimurium and Escherichia coli.The results show that mice no Nlrp6 gene is more likely to survive after the injection of a lethal dose of bacteria liquid,and this the liver and spleen of mice infected with the bacteria contain a small amount of bacteria,and the day and three days after the body contain high levels of monocytes and neutrophils,to sum up,missing the NLRP6 mice showed a stronger effect of the immune effect.The researchers thus revealing the NLRP6 oppressed activity can trigger the production of cytokines and other proteins,which will promote inflammation to fend off infection,the results reveal NLRP6 can regulate the nuclear factor kappa B and extracellular signal-regulated kinase pathway.Paras researchers said the findings are entirely unexpected,this is the first member of the NLR family have been reported to inhibit rather than activation of the innate immune effector.The study is supported by the National Institutes of Health and ALSAC.