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tony tony
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12 years ago
As it stated that RNA primase synthesizes the RNA primer in short segments why don't it synthesize it continuously? If it can synthesize small fragment then why it cannot keep continuing this synthesis? why does it leave the gaps?
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#1
12 years ago
I think you may be a bit confused: primase synthesises short RNA primers on DNA, not RNA. This primer is to allow DNA polymerase to form a complementary strand to the single stranded DNA (ssDNA) during DNA replication.

DNA polymerase cannot bind and polymerise to ssDNA to start replication on the ssDNA, so the primer  is necessary to facilitate this.

An overly long RNA primer would be pointless as it needs to be removed and replaced with DNA during replication, and as such primase has evolved to only synthesis short RNA primers.
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