I was looking up intracellular ion related things and I made a chart. My question is why is there so many medicines for taking positive charge out of cells, and why is there not a whole lot of conditions where you need to put positive charge back into a cell?
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TAKE POSITIVE CHARGE OUT OF CELLS
Local anesthetics, Class I antiarrhythmic agents, Various anticonvulsants sodium+ channel blockers ex. Lamictal (anticonvulsants)
Used in the treatment of cardiac arrhythmia potassium+ channel blockers ex. Metformin (sulfonylureas)
Antihypertensive drugs calcium+ channel blockers ex. Amlodipine,Lisinopril (angiotensin-converting-enzyme inhibitors (ACE inhibitors)
Important in creating sweat, digestive juices, and mucus. chloride- channel openers ex. 1,10-phenanthroline, which activates CFTR chloride channels.[1]
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PUT POSITIVE CHARGE INTO CELLS
Several toxins Sodium+ channel Openers ex. Aconitine
vasodilator,anticonvulsant,smooth muscle,analgesic potassium+ channel openers ex. Diazoxide,Minoxidil,Nicorandil,Pinacidil,Retigabine,Flupirtine
as a possible alternative treatment strategy for LEMS. calcium+ channel openers ex. Bay K8644, GV-58
joint and muscular pain chloride- channel blockers ex. Niflumic acid (The product of this gene (the CFTR protein) is a chloride ion channel)
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder in which a significant fraction of the presynaptic P/Q-type Ca(2+) channels critical to the triggering of neurotransmitter release at the neuromuscular junction (NMJ) are thought to be removed.