Top Posters
Since Sunday
5
a
5
k
5
c
5
B
5
l
5
C
4
s
4
a
4
t
4
i
4
r
4
Home Q & A Board Biology-Related Homework Help Biochemistry
New Topic  
ilanasw ilanasw
wrote...
Go to Answer
6 years ago
 A myoglobin similar to the example we did in class had the protonation of a histidine residue coupled to the oxidation of a heme. The histidine had a pKA of 6.0 when the heme is oxidized and 7.1 when the heme is reduced. At pH 9.5, the reduction potential of the heme is +275 mV vs NHE.

(a) Draw the thermodynamic box that describes this system
(b) Predict the reduction potential at pH 3.
(c) The net charge at the iron center really cycles between 0 and +1, as the nitrogens at the center of the porphyrin ring have a total net charge of -2. Assuming a dielectric constant of 6, predict the distance between the heme iron and the histidine side chain.
Read 265 times
1 Reply
Replies
Answer verified by a subject expert
clovebcloveb
wrote...
#1
Valued Member
Top Poster
Posts: 782
Rep: 62 1
6 years ago
Sign in or Sign up in seconds to unlock everything for free
This verified answer contains over 170 words.

Related Topics

terriroberts96
wrote...

6 years ago
This calls for a celebration Person Raising Both Hands in Celebration
cartoon
wrote...

Yesterday
Thanks
Evolution
wrote...

2 hours ago
Helped a lot
New Topic      
Quick Reply
Explore
Post your homework questions and get free online help from our incredible volunteers
  1320 People Browsing
Start New Topic Take the Tour CoursesNew Study Tools Topics Trending Browse by Textbook
Related Images
  
 288
  
 340
  
 415
Your Opinion
What percentage of nature vs. nurture dictates human intelligence?
Votes: 431
Previous poll results: Which country would you like to visit for its food?