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Home Q & A Board Biology-Related Homework Help Biochemistry
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ilanasw ilanasw
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7 years ago
 A myoglobin similar to the example we did in class had the protonation of a histidine residue coupled to the oxidation of a heme. The histidine had a pKA of 6.0 when the heme is oxidized and 7.1 when the heme is reduced. At pH 9.5, the reduction potential of the heme is +275 mV vs NHE.

(a) Draw the thermodynamic box that describes this system
(b) Predict the reduction potential at pH 3.
(c) The net charge at the iron center really cycles between 0 and +1, as the nitrogens at the center of the porphyrin ring have a total net charge of -2. Assuming a dielectric constant of 6, predict the distance between the heme iron and the histidine side chain.
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clovebcloveb
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Cdfields
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7 years ago
Brilliant ツ
karamsidhu1
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Yesterday
Thank you, thank you, thank you!
Natalie Price
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2 hours ago
Thanks for your help!!
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