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Home Q & A Board Biology-Related Homework Help Biochemistry
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Toni A Toni A
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11 years ago
According to wikipedia, "LPL is attached to the luminal surface of endothelial cells in capillaries. It is most widely distributed in adipose, heart, and skeletal muscle tissue." Does this mean that LPL is a membrane protein of endothelial cells, or is it a secreted enzyme? And if it is a secreted enzyme, how does it stay "attached on the luminal surface" as opposed to floating away in the blood?
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#1
11 years ago
It is an enzyme (everything that ends with an -ase s an enzyme, thats how you know its an enzyme). They may stay concentrated on the luminal surface b/c of a jelly like matrix or they are within a membrane? Im not exactly sure why though.
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#2
11 years ago
The exact mechanism that LPL uses to remain attached to the endothelial surface is still an area of active investigation.  Evidence indicates that the enzyme is secreted into the capillary lumen where it binds to heparan sulfate on the endothelial surface, which holds it in place so it can keep its activity localized to adipose tissue (which synthesizes it).
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