Top Posters
Since Sunday
w
3
w
3
e
3
3
r
3
b
2
M
2
V
2
f
2
c
2
c
2
K
2
New Topic  
EA EA
wrote...
Posts: 223
Rep: 7 0
10 years ago
Familial Meditarranean Fever results in short but reoccurring episode of fever, as well as pain in the chest, joints and abdomen. The disease occurs most frequently in individuals of Mediterranean descent. The gene responsible for FMF was discovered on chromosome 16 in 1997. The following pedigree shows the occurrence of this disorder in one family.

Identify the phenotypes and genotypes of all the people shown in the pedigree
 Attached file 
Thumbnail(s):
You must login or register to gain access to this attachment.
Read 2969 times
6 Replies
Replies
Answer accepted by topic starter
Doctor-2-BDoctor-2-B
wrote...
Donated
Valued Member
Top Poster
Posts: 1634
10 years ago
Sign in or Sign up in seconds to unlock everything for free
1
Pretty fly for a SciGuy

Related Topics

EA Author
wrote...
10 years ago
This is a recessive autosomal disorder (both males and females are affected, and two unaffecteds have affected offspring)
I 1: Ff   2: Ff
II 1: Ff   2: Ff    3: ff    4: F- (cannot know genotype because both offspring are unaffected)
III 1: ff   2: Ff (unaffected, so F-, but father is affected (ff), so must be Ff)    3: Ff   4: Ff
IV 1:F-  2: ff    3: F-
Phenotypes for white symbols: F or unaffected
Phenotypes for black symbols: f or affected


thank you Slight Smile)
wrote...
10 years ago
This is a recessive autosomal disorder (both males and females are affected, and two unaffecteds have affected offspring)
I 1: Ff   2: Ff
II 1: Ff   2: Ff    3: ff    4: F- (cannot know genotype because both offspring are unaffected)
III 1: ff   2: Ff (unaffected, so F-, but father is affected (ff), so must be Ff)    3: Ff   4: Ff
IV 1:F- 2: ff    3: F-
Phenotypes for white symbols: F or unaffected
Phenotypes for black symbols: f or affected

Shouldn't IV-1 be Ff because the Father is ff and the Mother is Ff?
wrote...
10 years ago
This is a recessive autosomal disorder (both males and females are affected, and two unaffecteds have affected offspring)
I 1: Ff   2: Ff
II 1: Ff   2: Ff    3: ff    4: F- (cannot know genotype because both offspring are unaffected)
III 1: ff   2: Ff (unaffected, so F-, but father is affected (ff), so must be Ff)    3: Ff   4: Ff
IV 1:F- 2: ff    3: F-
Phenotypes for white symbols: F or unaffected
Phenotypes for black symbols: f or affected

Shouldn't IV-1 be Ff because the Father is ff and the Mother is Ff?

you're right. IV-1 is Ff
wrote...
Donated
Valued Member
10 years ago
Yes.  My mistake.
Pretty fly for a SciGuy
wrote...
10 years ago
This is a good answer! Good job!
New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  492 People Browsing
Related Images
  
 865
  
 466
  
 362
Your Opinion
Which 'study break' activity do you find most distracting?
Votes: 824