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alexa_daneluk alexa_daneluk
wrote...
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12 years ago
Im working on my homework and im just not sure if Im answering the second part of the question right or if im missing anything? HELP!!

The question is -->State the Frank  Starling Law of the Heart, and explain its relationship to cardiac output using the appropriate formula for determining cardiac output. (2.5 marks)

My answer-->
The Frank-Starling Law of the Heart is the intrinsic relationship between the amount of ventricular stretching (amount of venous return) and the contractile force. This means that with an increase in the end-diastolic volume (caused by an increase in ventricular filling) the more the heart is stretched. This increase in the stretch of the heart causes a longer initial cardiac length before the hearts contraction. A greater force on the following heart contraction is due to the increase in cardiac length; furthermore, this causes an increase in the stroke volume. In other words this law states “more in = more out.”


Cardiac output is the amount of blood pumped by each ventricle each minute, furthermore, cardiac output is a product of how much blood the left ventricle pumps with each contraction (stoke volume) and heart rate. Cardiac output is directly related to venous return, which is the factor that determines the preload. When the heart rate is constant, the cardiac output is directly proportional to the preload. Therefore, an increase in preload will increase the cardiac output until a certain point (very high end diastolic volume). Additionally, any increase or decrease in the contractility of the cardiac muscle will increase or decrease the cardiac output. The Frank-Starling Law of the Heart is related to cardiac output can be seen in the formula CO= HR x SV (cardiac output = heart rate times stroke volume). For example seen in exercise a larger cardiac output is needed, therefore, there is an increase in venous return that is stimulated by the sympathetic nervous system. As a result, this increases end diastolic volume which in turn increases stroke volume. Additionally, heart rate is also increased during exercise. With the combined effects of an increase in stoke volume and an increase in heart rate this causes an increase in cardiac output. The benefit of an increase in cardiac output during exercise is an increase in blood flow to the working muscles.
Textbook 
Human Physiology: An Integrated Approach

Human Physiology: An Integrated Approach


Edition: 8th
Author:
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wrote...
Staff Member
12 years ago
The Frank-Starling law of the heart states that the critical factor controlling stroke volume is the degree of stretch of cardiac muscle cells immediately before they contract. In other words, the Frank-Starling law explains that the critical factor controlling stroke volume is the degree of stretch of the cardiac muscle cells just before they contract. The important factor in the stretching of cardiac muscle is the amount of blood returning to the heart and distending its ventricles.

Generally, an increase in filling time leads to an increase in end diastolic volume (Frank Starling mechanism). Wink Face

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alexa_daneluk Author
wrote...
12 years ago
Im not sure what the exact relationship is between the frank starling law and cardiac output?
wrote...
12 years ago
When there is more blood in the ventricle of the heart, the heart will contract more forcefully and increase stroke volume. This is pretty much the Frank-Starling effect.
Biology!
wrote...
Educator
12 years ago
Hey Alexa,

welcome to the forum...

The Frank-Starling effect describes the effect whereby greater filling of the ventricles results in a greater ventricular contraction. It allows the ventricles, effectively, to ?autoregulate? stroke volume, so that it can pump effectively. It allows the heart to automatically compensate for increases in the amount of blood returning to the heart. If the Frank-Starling effect didn?t exist, and the stroke volume of the heart was always constant, then in a situation in which venous return is increased, there would be ?leftover? blood in the heart after each contraction. This extra blood would build up over time, increasing in volume, until the heart was so distended that contraction would be ineffective.
alexa_daneluk Author
wrote...
12 years ago
Thank you!! I have another question that im waiting to be answered maybe you guys can help?

What is the one structural protein molecules seen in skeletal muscle fibers??
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