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itzadejo itzadejo
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10 years ago
If all-trans retinoic acid binds at a specific site of the protein CRABP does that mean that 13-cis retinoic acid would also bind there?
If not, then why not?
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#1
10 years ago
Quote from: itzadejo (10 years ago)
If all-trans retinoic acid binds at a specific site of the protein CRABP does that mean that 13-cis retinoic acid would also bind there?
If not, then why not?

I couldn't tell you if the cis isoform would bind there at all or not, but the enzyme would have less affinity for it. The three dimensional structure of the substrate must fit in the active site of an enzyme tightly for the reaction to occur at a reasonable rate. By changing the 3D structure of the substrate, it will likely cause the enzyme to either not bind it as tight or at all.
~Cooper
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#2
10 years ago
No, that doesn't mean that the cis molecule will bind there, because even d- and l- isomers have different binding sites, because these sites have a very high specificity in relation to their substrates.
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