Top Posters
Since Sunday
a
5
k
5
c
5
B
5
l
5
C
4
s
4
a
4
t
4
i
4
r
4
r
4
SlideshowReport

Regulation of translation in erythropoietic cells by heme levels

Description
If heme levels fall, the heme-controlled kinase becomes active and phosphorylates eIF2 (red arrow).

This blocks further translation by tying this factor into a stable complex with eIF2B.

When heme levels are adequate, the kinase is inhibited, and eIF2 is available for translation initiation.
Related Images
Add Comment
Explore
Post your homework questions and get free online help from our incredible volunteers
  1251 People Browsing
 122 Signed Up Today
Your Opinion
Who's your favorite biologist?
Votes: 586