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Action of the Pyruvate Dehydrogenase Complex

Description
Arsenic poisoning, both intentional and unintentional, has had a long history, dating back to at least the eighth century.

Trivalent As(III) compounds such as arsenite and organic arsenicals react readily with thiols, and they are especially reactive with dithiols, such as dihydrolipoamide, forming bidentate adducts
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