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SlideshowReport

Accurate lesion bypass by Pol h

Description
a. Structural distortion created when two adjacent thymine bases undergo UV-induced dimerization.

b. Human Pol in a ternary complex with dATP correctly positioned opposite the in the dimer in the template strand.

c. Crystal structure of human Pol in a ternary complex in which the DNA has been replicated by the addition of two nucleotides past the thymine dimer.
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