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SlideshowReport

Checkpoint Genes in Action

Description
Checkpoint genes in action. Radiation damaged the DNA inside
this nucleus. (A) Green dots pinpoint the location of the product of a gene called
53BP1; (B) red dots show the location of the BRCA1 gene product. Both proteins
have clustered around the same chromosome breaks in the same nucleus; both
function to recruit DNA repair enzymes. The integrated action of these and other
checkpoint gene products blocks mitosis until the DNA breaks are fixed.
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