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jco177 jco177
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6 years ago
What would be the effect of a genetic defect that resulted in a lack of somatic recombination between V, D, and J segments?
 
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6 years ago
An individual with this genetic defect would be unable to rearrange either immunoglobulin or T-cell receptor genes somatically. There would be a severe combined immunodeficiency (SCID) owing to the absence of mature B cells and T cells.
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