Several drugs have been developed over the past decade that target and bind to specific cytokines ...

Several drugs have been developed over the past decade that target and bind to specific cytokines (e.g., TNF-). What detrimental health effects result from blocking cytokines?
 
  A. The immune response will not be as robust because certain pathways have been blocked.
  B. Hyperstimulation of the immune system may result in a cytokine storm (hypercytokinemia).
  C. Excessive amounts of energy will be required to maintain the immune response when so many cytokines are present so the patient will require more than eight hours of sleep.
  D. Both A and B are potential concerns.
  E. Both B and C are potential concerns.