Describe the relationship between single nucleotide polymorphisms and haplotypes and explain how ...

Genome-wide association studies look for an association between the single nucleotide polymorphism markers and a trait. Haplotypes are combinations of SNPs located so close to each other on a chromosome that they are very often inherited together. In GWAS, researchers scan tens of thousands of genomes to see whether a particular haplotype is found significantly more often in people with a trait than in people without the trait. If so, a gene controlling that trait may be near the chromosome location of these SNPs, and candidate genes near the SNPs can be investigated.