Neispavani syndrome is a condition caused by a complete loss Of the nezgoda (nez) gene product. The nez promoter is paternally imprinted. In the pedigree below, individuals 1.1, 11.2, 11.4 and 111.1 are affected With Neispavani syndrome. Assigning the letters N to a functioning copy Of the gene, and n to a LOF mutation, what is the Of individual 11.4?
Select "nn"
You have discovered that excessive tail grooming in ricefield rats is caused by a recessive LOF mutation. Using the pedigree below, if 111-2 and 111-5 mate, what is the probability that if they have 3 offspring, exactly 2 would be unaffected and the other I would be affected?
For this question, assuming that the parents in the first generation are heterozygous, and the affect are homozygous recessive, we don't know if the genotype of III2 and III5 are NN or carriers Nn. There's literally a 50/50 chances they're either both NN or both Nn. If they're both NN, then there's a zero probability. If they are both carriers, Nn, then for the first child
AAA
ANN - 0.25 * 0.75 * 0.75 = 14%AAN
NNN
I think that's the answer.
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