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kyliesalm kyliesalm
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Why are eukaryotic mRNAs not polycistronic, unlike some bacterial transcripts?

▸ Eukaryote's genetic code is non-overlapping, and so coding sequences cannot overlap on the same mRNA.

▸ Eukaryotes have more complex translational machinery than bacteria that is also less efficient in initiating translation.

▸ Eukaryotic mRNAs are generally shorter than bacteria mRNAs, and so do not contain sufficient information to encode additional polypeptides.

▸ Bacteria couple their translation with transcription, while eukaryotes do not.

▸ The eukaryotic ribosome must bind to the 5' end of the mRNA and scan, while the bacterial ribosome can bind to a Shine-Delgarno sequence anywhere in the mRNA.
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Genetic Analysis: An Integrated Approach

Genetic Analysis: An Integrated Approach


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kater28kater28
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Thank you, thank you, thank you!
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Smart ... Thanks!
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