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robbie robbie
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2 years ago
Which lists the potential steps for genetic therapy for mice with sickle cell disease (βS/βS) in the correct order?

I.Differentiation of iPS cells into hematopoietic progenitor (HP) cells by infecting with retrovirus 
expressing HoxB4.
II.Reprogramming tail fibroblasts into induced pluripotent stem (iPS) cells by infecting them with 
viral vectors containing transcription factors.
III.Infection with a viral vector expressing Cre recombinase to remove transcription factor(s) from 
from iPS cells.
IV.Transplantation of corrected (βA/βA) hematopoietic cells back into irradiated mice.
V.Homologous recombination with βS and wild-type βA allele via CRISPR-Cas9 genome editing.


▸ I, II, III, V, IV

▸ II, III, V, I, IV

▸ V, III, IV, I, II

▸ V, III, I, IV, II

▸ II, III, IV, V, I
Textbook 
Genetic Analysis: An Integrated Approach

Genetic Analysis: An Integrated Approach


Edition: 3rd
Authors:
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Andylai01Andylai01
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2 years ago
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