× Didn't find what you were looking for? Ask a question
  
  
Top Posters
Since Sunday
r
6
u
5
b
4
r
4
o
4
d
4
n
4
l
4
V
3
3
m
3
s
3
New Topic  
Marco Atzori Marco Atzori
wrote...
Posts: 1
Rep: 0 0
5 months ago
Phase biotransformation reactions can be oxidations, reductions or hydrolysis of the xenobiota molecule.
Phase 1 oxidations are catalyzed by the cytocrome P450 enzyme, abbreviated with the CYP acronym: the active site of this enzyme is a prorphyrin ring in the center of which a Fe(III) atom is coordinated. When the enzyme binds to the substrate, the iron is oxidized to form the perferryl species FeVO, where iron has the unusual oxidation state +5. At this point the iron transfers, through a radical mechanism, the oxigeno atom to the substrate, reducing to \({Fe(III)}\) and restoring the enzyme.
This is for oxidations. Instead, I would like to know how the reductions always catalysed by the CYP work. In the books is reported the reduction always takes place at the expense of the iron, which from Fe(III) is transformed into Fe(V). But now, how does the enzyme restore the Fe(III)?
Read 122 times
1 Reply

Related Topics

Replies
Anonymous
wrote...
5 months ago
Hello,

Have you had a look at this article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519473/
New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  288 People Browsing
 325 Signed Up Today
Related Images
  
 2571
  
 213
  
 197
Your Opinion
What percentage of nature vs. nurture dictates human intelligence?
Votes: 328

Previous poll results: Do you believe in global warming?