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barry barry
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11 years ago
In the general population, 1 in 300 individuals is a carrier for Tay-Sachs disease, while 1 in 30 individuals of Ashkenazi Jew descent are carriers. Tay-Sachs also affects 1 in 30 individuals with French-Canadian ancestry, although two completely unique mutations are responsible for the Ashkenazi and French-Canadian mutations.

1) What are the chances of two individuals who are carriers having a child with Tay-Sachs if
   a.   both individuals are not of Ashkenazi or French-Canadian descent?
   b.   one individual is of Ashkenazi descent and one is not?
   c.   both individuals are of Ashkenazi descent?
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#1
Staff Member
11 years ago
For each question, you will calculate
[Chance of mom being a carrier] × [Chance of dad being a carrier] × [Chance of having an affected child if both parents are carriers]
a.   (1/300) × (1/300) × 1/4 = 2.77 × 10-6
b.   (1/30) × (1/300) × 1/4 = 2.77 × 10-5
c.   (1/30) × (1/300) × 1/4 = 2.77 × 10-4
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