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madisonbodiford madisonbodiford
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6 years ago
In the general population, 1 in 300 individuals is a carrier for Tay-Sachs disease, while 1 in 30 individuals of Ashkenazi Jew descent are carriers.
 
  Tay-Sachs also affects 1 in 30 individuals with French-Canadian ancestry, although two completely unique mutations are responsible for the Ashkenazi and French-Canadian mutations. What are the chances of two individuals who are carriers having a child with Tay-Sachs if a. both individuals are not of Ashkenazi or French-Canadian descent? b. one individual is of Ashkenazi descent and one is not? c. both individuals are of Ashkenazi descent?
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#1
6 years ago
For each question, you will calculate
Chance of mom being a carrier  Chance of dad being a carrier  Chance of having an affected child if both parents are carriers
a. (1/300 )  (1/300 )  1/4 = 2.77  106
b. (1/30 )  (1/300 )  1/4 = 2.77  105
c. (1/30 )  (1/30 )  1/4 = 2.77  104
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