Hemophilia is a genetic disease that has plagued the royal houses of Europe sinc

Hemophilia is a genetic disease that has plagued the royal houses of Europe since the time of Queen Victoria, who was a carrier. Her granddaughter, Alexandria, married Nicholas II, the last czar of imperial Russia. Alexandria was a carrier for hemophilia, but Nicholas was normal. Their son, Alexis, was afflicted with the disease. Alexis and his four sisters were all killed in 1917.

Based on this scenario, it is most likely that:
A) none of the four sisters carried the hemophilia gene.
B) each of the sisters had a 50% chance of being a carrier of the gene.
C) all four sisters were carriers of the hemophilia gene.
D) at least one of the sisters had hemophilia like Alexis.
E) Alexis inherited the hemophilia gene from Nicholas II.