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Home Q & A Board Biology-Related Homework Help Cell Biology
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faraz faraz
wrote...
13 years ago
What specific cytoskeletal protein has its function altered as the ultimate effect of digitalis?
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#1
Educator
13 years ago Edited: 13 years ago, bio_man
What course is this for?

I would say alpha-adducin

Moreover, Digitalis also disrupts cytoskeletal functions by inhibiting alpha-tubulin polymerization into microtubules!
wrote...
#2
Staff Member
13 years ago
Faraz:

Digitalis alkaloids: Na+/ K+-ATPase inhibitors => intracellular Na+ raises => Na+/Ca2+ exchange less efficient => Ca2+ intracellular increases => stronger contractions

high intracellular Ca2+ ions can inhibit the assembly of microtubules (tubulin being the major component of cytoplasmic microtubules) and, therefore, play a role in the regulation of microtuble formation.

Makes sense?
- Master of Science in Biology
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