How nucleosomes are positioned

Hey guys!

I'm starting quite an interesting literature project on whether/how nucleosomes are positioned in the genome. It's fairly open-ended and meant to test research skills on an emerging topic.  The main questions I will try to answer on this subject will be:

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How are nucleosomes positioned and organised in the genomes of different species? (Comparison between organisms)

Is positioning information an intrinsic part of DNA, is it governed by the histone interaction, is it mediated by the cell environment- or a combination of all of these?

What defects and diseases are related to nucleosome positioning defects?

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These I think are good questions to answer to make an interesting an informative report. However if anyone has any other areas they think would be interesting to research into, any ideas would be very welcome.

It's a pretty cool subject, and for those who aren't familiar with this topic Jiang and Pugh have an excellent introductory review.
http://www.nature.com/nrg/journal/v10/n3/full/nrg2522.html


Thanks!