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Home Q & A Board Biology-Related Homework Help Cell Biology
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Dino_bergomi Dino_bergomi
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9 years ago
Does anybody know how Importins recruit cargo (proteins, etc) to inside the nucleus? I know that there are specific peptide signals (NLSs) to trigger this, but my question is:
(i) Does the cargo need to be in the vicinity of the nucleus to bind to importins, and be imported; or (ii) are importins able to recruit the cargo from anywhere inside the cell, and traffic it to the nucleus? (This is not so easy to ask google, and not so easy for a non-biologist/biochemist to research the literature in a couple of hours…)
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#1
Educator
9 years ago
I just did a PubMed search: https://biology-forums.com/results.php?cx=003130469996065852161%3Axfl7_wz0vje&cof=FORID%3A10&ie=UTF-8&hl=en&as_filetype=PDF&q=importins+bind+nucleus&sa=Search and there are so many factors to consider. Hopefully the link I provide steers you in the right direction.
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