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farhan ali farhan ali
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4 years ago
Design an artificial molecule based on antibody or its fragment(s) for certain purpose and explain your design.

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Educator
4 years ago
Hi farhan ali, a few things to keep in mind.

Antibodies are proteins; they bind to antigens (that are also proteins) by reversible, noncovalent interactions, including hydrogen bonds, hydrophobic interactions, and charge-based interactions.

The parts of antigens that are recognized by antibodies are called epitopes, or determinants. Some epitopes of protein antigens may be a contiguous stretch of amino acids in the primary structure of the protein; these are called linear epitopes.

Sometimes, amino acids that are not next to one another in the primary structure may be brought into proximity when the protein folds, forming a distinct shape that is recognized by an antibody; such determinants are called conformational epitopes.

To design your molecule, you could create a polypeptide that has complementary bases to that of the antibody antigen-binding site.

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