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EXERCISE 4
Endocrine System PhysiologyMetabolism The following questions refer to Activity 1: Determining Baseline Metabolic Rates.
1. Which rat had the fastest baseline metabolic rate?
2. Compare the baseline metabolic rates for the thyroidectomized rat and the normal rat and explain your results.
3. Compare the baseline metabolic rates for the hypophysectomized rat and the normal rat and explain your results.
The following questions refer to Activity 2: Determining the Effect of Thyroxine on Metabolic Rate. 4. What effect did administering thyroxine have on each of the rats?
5. Explain why thyroxine had these effects.
The following questions refer to Activity 3: Determining the Effect of TSH on Metabolic Rate. 6. Was there a change in the metabolic rate of the thyroidectomized rat with the administration of TSH? Explain your results.
7. Did the results for the thyroidectomized rat indicate hyperthyroidism or hypothyroidism?
The following questions refer to Activity 4: Determining the Effect of Propylthiouracil on Metabolic Rate.
8. Describe the effect of administering propylthiouracil on each of the rats, and explain why it had this effect.
9. Do you think the drug propylthiouracil is used to treat hypothyroidism or hyperthyroidism? Explain your answer.
Hormone Replacement Therapy
The following questions refer to Activity 5: Hormone Replacement Therapy. 10. Explain why ovariectomized rats were used in this experiment and correlate this to their baseline T score.
11. Recap your predictions regarding the effects of calcitonin and estrogen on bone density and explain why you made those predictions.
12. Why was one of the ovariectomized rats injected with saline?
13. What effect did the administration of estrogen injections have on the estrogen-treated rat?
14. What effect did the administration of calcitonin injections have on the calcitonin-treated rat?
15. How did your results compare to your predictions?
Insulin and Diabetes
The following question refers to Activity 6: Obtaining a Glucose Standard Curve. 16. What is a glucose standard curve, and how can you use this tool to determine a concentration of glucose?
The following questions refer to Activity 7: Measuring Fasting Plasma Glucose.
17. Which patient(s) had glucose reading(s) in the normal range?
18. Which patient(s) had glucose reading(s) in the diabetic range?
19. Which patient(s) had glucose reading(s) in the impaired range?
20. Describe the diagnosis for Patient 3.
The following questions refer to Activity 8: Measuring Cortisol and Adrenocorticotropic Hormone.
21. Which patient would most likely be diagnosed with Cushing’s disease? Why?
22. Which two patients have hormone levels characteristic of Cushing’s syndrome?
23. Patient 2 is being treated for rheumatoid arthritis with prednisone. How does this change the diagnosis?
24. Which patient would most likely be diagnosed with Addison’s disease? Why?