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Do first generation chimeras transmit genes from both parental strains?

Binah

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Posts: 2

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12 years ago

Do first generation chimeras transmit genes from both parental strains?

So this is very simple: I made injections of 1 engineered chromosome into Bl6 blastocysts, and I got my chimeras. I will next check for germline transmission on males, but my question is, does chimeric sperm also contain the Bl6 genetic background, or is it only derived from the engineered stem cells I used in the injections? From what I have read spermlines are derived from a handful of cells, but I'm not sure whether recombination occurs or the similar.

Thanks

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duddy

wrote...

#1

Staff Member

12 years ago

It gets passed on to the progeny, so it does contain the engineered chromosome.

- Master of Science in Biology
- Bachelor of Science

Binah Author

wrote...

#2

12 years ago

Thanks for your reply duddy, but once again, is sperm completely from the engineered ES cells, or does it contain Bl6 DNA? That's my question. I know the engineered chromosome is passed onto progeny, but not sure about the background.

duddy

wrote...

#3

Staff Member

12 years ago

Quote from: Binah (12 years ago)

Thanks for your reply duddy, but once again, is sperm completely from the engineered ES cells, or does it contain Bl6 DNA?

Of course, however, due to epigenetics, genes found on that chromosome may be turned off in certain regions of the body. So, the spermatogenic cells inside the seminiferous tubules do contain the chromosome, so it is a combination.

- Master of Science in Biology
- Bachelor of Science

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