Imagine that your goal is to isolate mouse mutants that stabilize microsatellite repeat sequences ...

Imagine that your goal is to isolate mouse mutants that stabilize microsatellite repeat sequences (i.e., lower the frequency at which their repeat number changes). Which of the following mutations would you predict to have this stabilizing effect?
A) a mutation that reduces the rate of transcription
B) a mutation that reduces the rate of translation
C) a mutation that increases the rate of DNA synthesis
D) a mutation that reduces the occurrence of homologous recombination
E) a mutation that inactivates reverse transcriptase and/or integrase