Conservation of enhancer sequences

The enhancer sequence of beta-interferon contains multiple sequences (colored boxes) conserved among mammalian species. Highlighted sequences are crucial to binding of specific regulatory proteinsThe enhancer sequence of beta-interferon contains multiple sequences (colored boxes) conserved among mammalian species. Highlighted sequences are crucial to binding of specific regulatory proteins

Bound protein ATF Jun IRF IRF IRF IRF NF-KB Human AAATGTAAATGACATAGGAAAACTGAAAG GGAGAAGTGAAAGT CTCTGAAT Nknme ...... AAATGACATAGGAAAACTGAAAGGGAGAA CTGAAAGT CTCTGA.. Rat ...... AAATGACGTAGGAAAAGTGAAAGGGAGAA CTGAAAGT CTCTGA.. Smfine ...... AAATGACATAGGAAAACTGAAAGGGAGAA CTGAAAGT CTCTGAA. Home .AATGTAAATGACATAGGAAAACAGAAAG GGAGAACTGAAAGT BOWneZ ..... TAAATGACATAGGAAAACTGAAAGGGAGA ACTGAAAGT BOWne ..... TAAATGACATAGGAAAAATGAAAGCGAGA ACTGAAAGT CTCTGAA. CTCC.... CTCT....