Activation of clotting mechanism results in intravascular clotting. Clot formation uses up the platelets and coagulation factors much faster than they can be replenished by the body. Because the fibrinolytic system is also activated at the same time as the coagulation system, it results in the lysis of clots to prevent obstruction of the circulatory system. The degradation products of this lysis further inhibit the clotting process. Because both platelets and coagulation factors are consumed and not replenished fast enough, the net effect is systemic hemorrhage.

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