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Home Q & A Board Biology-Related Homework Help Medicine Immunology
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life_skals life_skals
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6 years ago
There are many defects that result in severe combined immunodeficiency disorder. List
  four and briefly define them.
 
  What will be an ideal response
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#1
6 years ago
1. Reticular dysgenesisstem cell defect in which neither the lymphoid or myeloid line is produced.
2. Adenosine deaminase (ADA) deficiencyADA detoxifies adenosine and deoxyadenosine nucleotides. When it is
missing, cells die. Rapidly replaced cells such as lymphocytes are the most vulnerable.
3. Il-2 receptor defectT lymphocytes and NK cells are absent; B cells are nonfunctional.
4. RAG1 and RAG2 deficiencyT and B cell receptor gene rearrangements cannot occur, so T and B cells fail to
develop.
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