× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
a
5
k
5
c
5
B
5
l
5
C
4
s
4
a
4
t
4
i
4
r
4
r
4
Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
New Topic  
Fignshev Fignshev
wrote...
Posts: 678
Rep: 0 0
6 years ago
Li-Fraumeni syndrome is a rare inherited disease that greatly increases a person's risk of developing several types of cancer. This disease stems from a mutation in the TP53 tumor suppressor gene (Nichols et al. 2001.
 
  Cancer Epidemiol Biomarkers Prev 10:83-87). In most cases, approximately 95 of the mutations can be detected by sequence analysis of exons 4 through 9. If you isolated and analyzed DNA from a Li-Fraumeni patient, what genotype should you find in DNA isolated from a. normal tissue? b. malignant tissue?
Read 49 times
1 Reply

Related Topics

Replies
wrote...
#1
6 years ago
(a) The DNA from normal tissue should reveal one loss-of-function TP53 mutation (TP53-/TP53+).
(b) Malignant tissue should show loss of both alleles (TP53-/TP53-).
New Topic      
Quick Reply
Explore
Post your homework questions and get free online help from our incredible volunteers
  1135 People Browsing
Start New Topic Take the Tour CoursesNew Study Tools Topics Trending Browse by Textbook
Live Chat
Related Images
  
 1106
  
 46
  
 879
Your Opinion
Who's your favorite biologist?
Votes: 586
Previous poll results: Who will win the 2024 president election?