Pharmacokinetics

Problem  (Questions A-F).

The pharmacokinetics of amrinone after a single IV bolus injection (75 mg) in 14 healthy adult male volunteers followed a two-compartment open model and fit the following equation:

CP = Ae-αt + Be-βt

Where

A = 4.62 ± 12.0 μg/mL

B = 0.64 ± 0.17 μg/mL

α = 8.94 ± 13 h−1

β = 0.19 ± 0.06 h−1

A.) What is the volume of the central compartment (VC)?

B.) What is the volume of the peripheral/tissue compartment (VP)?

C.) What is the transfer rate constant from the central compartment to the central peripheral/tissue (k12)?

D.) What is the transfer rate constant from the peripheral/tissue compartment to the central compartment (k21)?

E.) What is the elimination rate constant from the central compartment (k10)?

F.) What is the elimination half-life (t1/2β) after the drug has equilibrated with the peripheral/tissue compartment?