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Home Q & A Board Biology-Related Homework Help Cell Biology
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barry barry
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Posts: 11630
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12 years ago
Li-Fraumeni syndrome is a rare inherited disease that greatly increases a person's risk of developing several types of cancer. This disease stems from a mutation in the TP53 tumor suppressor gene (Nichols et al. 2001. Cancer Epidemiol Biomarkers Prev 10:83-87). In most cases, approximately 95% of the mutations can be detected by sequence analysis of exons 4 through 9. If you isolated and analyzed DNA from a Li-Fraumeni patient, what genotype should you find in DNA isolated from

a. normal tissue?
b. malignant tissue?
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#1
Staff Member
12 years ago
(a) The DNA from normal tissue should reveal one loss-of-function TP53 mutation (TP53-/TP53+).
(b) Malignant tissue should show loss of both alleles (TP53-/TP53-).
- Master of Science in Biology
- Bachelor of Science
barry Author
wrote...
#2
12 years ago
Very well answered Smiling Face with Open Mouth
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