
Genes that help control inflammation leads to longer lifespans for humans and other species, and more of these genes a species has, the longer it can live.
Genes encoding some inflammation-dampening molecules are more numerous in longer-lived species, such as humans, than in short-lived animals such as mice. The genes produce proteins known as
CD33-related Siglecs. Siglecs are proteins that recognize different versions of
sialic acid – sugars that are found at all cell surfaces of vertebrates and some invertebrates.
By distinguishing between different versions of sialic acid, the proteins help the immune system decide which cells are normal residents of the body and which are intruders. In addition, the proteins soothe inflammation in the aft ...