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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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Basketball1121 Basketball1121
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6 years ago
RNA interference (or RNAi) is a popular research tool used in biomedical research. It has great potential as it allows researchers to knock down, or silence, genes of interest. For, example, it could be used to block expression of a gene that plays a role in a certain cancer. In the lab, researchers can design synthetic double stranded RNA that then binds the mRNA of interest and leads to its destruction. Which mechanism within a cell also leads to mRNA destruction? Explain how this mechanism works.
 
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6 years ago
MicroRNAs also lead to mRNA destruction. MicroRNAs are encoded within the genome and they are used as a tool in the cell to control gene expression. By leading to mRNA destruction, the protein encoded by the specific mRNA will not be translated. A microRNA is complementary in sequence to a part of an mRNA so that they basepair and form small regions of double-stranded RNA. The double-stranded RNA is cut into small pieces by specific cellular machinery (enzyme complexes). These enzymes then destroy any RNA in the cell that are complementary to the microRNA sequences.
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